PRESENTATION: Telmisartan 40mg+Chlorthalidone 12.5 Mg+Amlodipine 5mg Tablets

DRUG CLASS: ARB+THIAZIDE DIURETIC+CCB

MECHANISM OF ACTION: Telmisartan is a non-peptide AT1 angiotensin II receptor antagonist. It exerts antihypertensive activity by preventing angiotensin II from binding to AT1 receptors thus inhibiting the vasoconstricting and aldosterone-secreting effects of angiotensin II. Chlorthalidone improves blood pressure and swelling by preventing water absorption from the kidneys through inhibition of the Na+/Cl− symporter in the distal convoluted tubule cells in the kidney. The exact mechanism of chlorthalidone's anti-hypertensive effect is under debate, however, it is thought that increased diuresis results in decreased plasma and extracellular fluid volume, decreased cardiac output and therefore overall reduction in blood pressure. Amlodipine has selectivity for the peripheral blood vessels, with a lower incidence of myocardial depression and cardiac conduction abnormalities than other calcium channel blockers.Amlodipine has antioxidant properties and an ability to enhance the production of nitric oxide (NO), an important vasodilator that decreases blood pressure.

INDICATIONS: Hypertension

DOSAGE: As Directed by the Physician