PRESENTATION: Telmisartan 40mg+Chlorthalidone 12.5 Mg Tablets

DRUG CLASS: Angiotensin II antagonists+Thiazide diuretic

MECHANISM OF ACTION: Telmisartan is a non-peptide AT1 angiotensin II receptor antagonist. It exerts antihypertensive activity by preventing angiotensin II from binding to AT1 receptors thus inhibiting the vasoconstricting and aldosterone-secreting effects of angiotensin II. Chlorthalidone improves blood pressure and swelling by preventing water absorption from the kidneys through inhibition of the Na+/Cl− symporter in the distal convoluted tubule cells in the kidney. The exact mechanism of chlorthalidone's anti-hypertensive effect is under debate, however, it is thought that increased diuresis results in decreased plasma and extracellular fluid volume, decreased cardiac output and therefore overall reduction in blood pressure.

INDICATIONS: For the treatment of hypertension.

DOSAGE: As Directed by the Physician