PRESENTATION: Telmisartan 40mg+Amlodipine 5mg/Cilnidipine 10mg Tablets 

DRUG CLASS: ARB+CCB+CCB 

MECHANISM OF ACTION: Telmisartan is a non-peptide AT1 angiotensin II receptor antagonist. It exerts antihypertensive activity by preventing angiotensin II from binding to AT1 receptors thus inhibiting the vasoconstricting and aldosterone-secreting effects of angiotensin II.  Amlodipine belongs to the group of drugs called dihydropyridine calcium channel blockers.Amlodipine has selectivity for the peripheral blood vessels, with a lower incidence of myocardial depression and cardiac conduction abnormalities than other calcium channel blockers.Amlodipine has antioxidant properties and an ability to enhance the production of nitric oxide (NO), an important vasodilator that decreases blood pressure.Cilnidipine acts on the L-type calcium channels of blood vessels by blocking the incoming calcium and suppressing the contraction of blood vessels, thereby reducing blood pressure. Cilnidipine also works on the N-type calcium channel located at the end of the sympathetic nerve, inhibiting the emission of norepinephrine and suppressing the increase in stress blood pressure.Cilnidipine is indicated for the management of hypertension for end-organ protection. It is reported to be useful in elderly patients and in those with diabetes and albuminuria. Cilnidipine has been increasingly used in patients with chronic kidney disease 

INDICATIONS: For the management of hypertension and end-organ protection. 

DOSAGE: As Directed by the Physician