PRESENTATION: Rosuvastatin 5, 10, & 20 mg tablets

DRUG CLASS: Antilipemic Agent, HMG-CoA Reductase Inhibitor

MECHANISM OF ACTION: Rosuvastatin is an Inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, the rate-limiting enzyme in cholesterol synthesis (reduces the production of mevalonic acid from HMG-CoA); this then results in a compensatory increase in the expression of LDLreceptors on hepatocyte membranes and a stimulation of LDL catabolism.In addition to the ability of HMG-CoA reductase inhibitors to decrease levels of high-sensitivity C-reactive protein (hsCRP), they also possess pleiotropic properties including improved endothelial function,reduced inflammation at the site of the coronary plaque, inhibition of platelet aggregation, and anticoagulant effects.

INDICATIONS: Hyperlipidemia and Mixed Dyslipidemia, Hypertriglyceridemia, Primary

Dysbetalipoproteinemia (Type III Hyperlipoproteinemia), Homozygous, Familial, Hypercholesterolemia,Slowing of the progression of atherosclerosis, Primary Prevention of Cardiovascular Disease.

DOSAGE: As Directed by the Physician