PRESENTATION: Olmesartan 20mg/40mg +Chlo 12.5 Mg+ Chlorthalidone 12.5 Mg Tablets

DRUG CLASS: Angiotensin 2 Receptor Blocker+ Thiazide diuretic

MECHANISM OF ACTION:  Olmesartan - Angiotensin receptor blockade.

Chlorthalidone is a thiazide-like diuretic used for the treatment of hypertension and for management of edema caused by conditions such as heart failure or renal impairment. Chlorthalidone improves blood pressure and swelling by preventing water absorption from the kidneys through inhibition of the Na+/Cl− symporter in the distal convoluted tubule cells in the kidney. The exact mechanism of chlorthalidone's anti-hypertensive effect is under debate, however, it is thought that increased diuresis results in decreased plasma and extracellular fluid volume, decreased cardiac output and therefore overall reduction in blood pressure.

INDICATIONS: Hypertension

DOSAGE: As Directed by the Physician