PRESENTATION: Pioglitazone 7.5/15, GLIMEPIRIDE 1MG/2MG +METFORMIN 500MG SR +PIOGLITAZONE 15MG

DRUG CLASS: Thiazolidinediones, Sulfonylurea (Glimepiride) & Biguanide (Metformin)

MECHANISM OF ACTION:  

Pioglitzone : Pioglitazone is a potent and selective agonist for peroxisome proliferator-activated receptor-gamma (PPARgamma).

 Activation of nuclear PPARgamma receptors influences the production of a number of gene products involved in glucose and lipid metabolism.

PPARgamma is abundant in the cells within the renal collecting tubules; fluid retention results from stimulation by thiazolidinediones which increases sodium reabsorption.

Glimepiridestimulates insulin release from the pancreatic beta cells; reduces glucose output from the liver; insulin sensitivity is increased at peripheral target sites.

Metformin decreases hepatic glucose production, decreasing intestinal absorption of glucose and improves insulin sensitivity (increases peripheral glucose uptake and utilization)

INDICATIONS & DOSAGE: As Directed by the Physician