PRESENTATION: Clopidogrel 75mg/Aspirin 75mg 

DRUG CLASS: P2Y12 inhibitors + Non-selective cyclooxygenase (COX) inhibitor 

MECHANISM OF ACTION: 

Clopidogrel is metabolized to its active form by carboxylesterase-1. The active form is a platelet inhibitor that irreversibly binds to P2Y12 ADP receptors on platelets. This binding prevents ADP binding to P2Y12 receptors, activation of the glycoprotein GPIIb/IIIa complex, and platelet aggregation.Aspirin (Acetylsalicylic acid - ASA) The inhibition of platelet aggregation by ASA occurs because of its interference with thromboxane A2 in platelets, caused by COX-1 inhibition. Thromboxane A2 is an important lipid responsible for platelet aggregation, which can lead to clot formation and future risk of heart attack or stroke. 

INDICATIONS: Treatment or Prevention of heart attack and stroke 

DOSAGE: As Directed by the Physician